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null Grupo del Hospital Universitario Donostia (Guipúzcoa)

Hospital Universitario Donostia (Guipúzcoa)

Description

The research group on AIDS and HIV infection at the Donostia University Hospital began its research activity in the 1990s, initially participating in clinical trials and collaborative studies with various groups, especially GESIDA. In 2004, our group was already part of the first AIDS Research Network, where has stayed until present. We currently follow-up approximately 1,500 HIV-infected patients and we are involved in the improvement of our patients care through clinical research within a sustainable framework. In this regard, the key areas of interest of our group are four:

  • Epidemiological studies in the cohort of HIV-infected patients, with special interest in survival and related factors; as well as in opportunistic infections, comorbidity, aging and new forms of care.
  • Antiretroviral treatment and its complications, with participation throughout the last years in more than 50 antiretroviral clinical trials.
  • Hepatitis virus coinfection, working with other groups of the country in collaborative efforts led with the endorsement of CoRIS or GESIDA.
  • Prevention of late diagnosis and HIV infection.

Regarding our scientific production itself or directly led by our group, it should be noted the doctoral theses. The defended theses are the following: 

  • Natural history of HIV infection in Gipuzkoa (1990)
  • AIDS: clinical-epidemiological aspects, survival analysis and prognostic factors (1990)
  • Viral load rebound in patients with HIV infection: magnitude of the problem, associated factors and risk of virological failure (2016)

We are currently performing three doctoral theses:

  • Mortality and the factors correlated with it in HAART era, analyzing factors poorly studied until now such as temporary follow-up losses
  • Comorbidity in the HIV-infected patient
  • Historical evolution of the treatment of hepatitis C virus chronic infection in a cohort of patients from Donostia University Hospital co-infected with the human immunodeficiency virus (HIV).

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Members

Jose Antonio Iribarren
Harkaitz Azkune
Mª Jesús Bustinduy
Xabier Camino
Miguel Ángel Goenaga
Maialen Ibarguren
Xabier Kortajarena
Francisco Rodríguez
Miguel Ángel von Wichmann

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Publications

  • A case-control study of non-AIDS-defining cancers in a prospective cohort of HIV-infected patients. 
    Rodríguez Arrondo F, von Wichmann MÁ, Camino X, Goenaga MÁ, Ibarguren M, Azcune H, Bustinduy MJ, Ferrero O, Muñoz J, Ibarra S, Aguirrebengoa K, Goicoetxea J, Bereciartua E, Montejo M, García MA, Martínez E, Portu J, Metola L, Silvariño R, Sarasqueta C, Arrizabalaga J, Iribarren JA; (Grupo SEINORTE).  Med Clin (Barc). 2017 May 18. pii: S0025-7753(17)30277-4. doi: 10.1016/j.medcli.2017.03.032. [Epub ahead of print] English, Spanish. PMID: 28528797 
  • Prevention and treatment of opportunistic infections and other coinfections in HIV-infected patients: May 2015. 
    Iribarren JA, Rubio R, Aguirrebengoa K, Arribas JR, Baraia-Etxaburu J, Gutiérrez F, Lopez Bernaldo de Quirós JC, Losa JE, Miró JM, Moreno S, Pérez Molina J, Podzamczer D, Pulido F, Riera M, Rivero A, Sanz Moreno J, Amador C, Antela A, Arazo P, Arrizabalaga J, Bachiller P, Barros C, Berenguer J, Caylá J, Domingo P, Estrada V, Knobel H, Locutura J, López Aldeguer J, Llibre JM, Lozano F, Mallolas J, Malmierca E, Miralles C, Miralles P, Muñoz A, Ocampo A, Olalla J, Pérez I, Pérez Elías MJ, Pérez Arellano JL, Portilla J, Ribera E, Rodríguez F, Santín M, Sanz Sanz J, Téllez MJ, Torralba M, Valencia E, Von Wichmann MA; GESIDA/SEIMC Writing Committee.  Enferm Infecc Microbiol Clin. 2016 Oct;34(8):516.e1-516.e18. doi: 10.1016/j.eimc.2016.02.004. Epub 2016 Mar 11. PMID: 26976381 
  • Executive summary: Prevention and treatment of opportunistic infections and other coinfections in HIV-infected patients: May 2015. 
    Iribarren JA, Rubio R, Aguirrebengoa K, Arribas JR, Baraia-Etxaburu J, Gutiérrez F, Lopez Bernaldo de Quirós JC, Losa JE, Miró JM, Moreno S, Pérez Molina J, Podzamczer D, Pulido F, Riera M, Rivero A, Sanz Moreno J, Amador C, Antela A, Arazo P, Arrizabalaga J, Bachiller P, Barros C, Berenguer J, Caylá J, Domingo P, Estrada V, Knobel H, Locutura J, López Aldeguer J, Llibre JM, Lozano F, Mallolas J, Malmierca E, Miralles C, Miralles P, Muñoz A, Ocampo A, Olalla J, Pérez I, Pérez Elías MJ, Pérez Arellano JL, Portilla J, Ribera E, Rodríguez F, Santín M, Sanz Sanz J, Téllez MJ, Torralba M, Valencia E, Von Wichmann MA; GESIDA/SEIMC Writing Committee.  Enferm Infecc Microbiol Clin. 2016 Oct; 34(8):517-23. doi: 10.1016/j.eimc.2016.02.025. Epub 2016 Apr 5.PMID: 27056581 
  • Present and future of darunavir for the treatment of human immunodeficiency virus infection. 
    Iribarren JA.  Enferm Infecc Microbiol Clin. 2016 May; 34 Suppl 1:34-40. doi: 10.1016/S0213-005X (17)30007-1. Spanish. No abstract available. PMID: 28081762 
  • Low risk of liver decompensation among human immunodeficiency virus/hepatitis C virus-coinfected patients with mild fibrosis in the short term. 
    Macías J, Mancebo M, Márquez M, Merino D, Téllez F, Rivero A, Von Wichmann MA, López-Cortés LF, Merchante N, Santos J, Raffo M, Pérez-Pérez M, Camacho Á, Iribarren JA, Pineda JA.  Hepatology. 2015. May; 61(5):1503-11. doi: 10.1002/hep.27674. Epub 2015 Mar 20. PMID: 25545020 
  • Outcomes in HIV-infected patients admitted due to pandemic influenza. 
    López-Aldeguer J, Iribarren JA, Valencia E, Barquilla E, Knobel H, Santos J, Lozano F; the GESIDA 6409 Study Group.  Enferm Infecc Microbiol Clin. 2012 Mar 27. [Epub ahead of print] 
  • Prevention of HIV transmission (vertical, occupational and non-occupational). 
    Azkune H, Ibarguren M, Camino X, Iribarren JA.  Enferm Infecc Microbiol Clin. 2011 Oct; 29(8):615-25 
  • Long-term effectiveness and safety outcomes in HIV-1-infected patients after a median time of 6 years on nevirapine. 
    Rodríguez-Arrondo F, Aguirrebengoa K, Portu J, Muñoz J, García MA, Goikoetxea J, Martínez E, Iribarren JA, Perez-Alvarez N, Negredo E, Clotet B.  Curr HIV Res. 2009 Sep; 7(5):526-32. PubMed PMID: 19925403 
  • Clinical manifestations of HIV infection in distinct geographical áreas. 
    Iribarren JA, Rivas González P, Amador Prous C, Velasco Arribas M.  Enferm Infecc Microbiol Clin. 2008 May;26 Suppl 5:6-11. Review. PMID: 18590661 
  • Effectiveness and safety of simplification therapy with once-daily tenofovir, lamivudine, and efavirenz in HIV-1-infected patients with undetectable plasma viral load on HAART. 
    Arrizabalaga J, Arazo P, Aguirrebengoa K, García-Palomo D, Chocarro A, Labarga P, Muñoz-Sánchez MJ, Echevarría S, Oteo JA, Uriz J, Letona S, Fariñas MC, Peralta G, Pinilla J, Ferrer P, Alvarez ML, Iribarren JA.  HIV Clin Trials. 2007 Sep-Oct; 8(5):328-36. PMID: 17956834 

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