María Rosa López-Huertas - María Rosa López-Huertas
PhD in Molecular Biology. Universidad Autónoma de Madrid.
I get started in HIV-1 infection at the AIDS Immunopathology Unit, Instituto de Salud Carlos III (ISCIII) (Madrid). My PhD studies (2003-2008) described the shuttle of NF-kB during HIV-1 replication in non-activated T cells. Then, I worked as a Postdoctoral Research Fellow at AIDS Immunopathology Unit (ISCIII, Madrid) and Human Virology Department (École Normale Supérieure-INSERM U758, Lyon) (2008-2015). My interests focused on describing the cellular modifications induced by Tat during viral replication and on blocking the protein kinase theta to prevent HIV-1 infection in T lymphocytes.
I have worked since 2015 at the Infectious Diseases Service (Instituto Ramón y Cajal de Investigación Sanitaria – IRYCIS, Madrid) where I have get into clinical research as remain closer within my field of expertise.
The projects included finding cellular miRNA involved in viral latency and the combination of maraviroc with other latency reversal drugs to reactivate HIV-1 reservoirs. Currently, I am studying the possible use of tyrosine kinase inhibitors in the treatment and / or cure of HIV. Since 2012, I have also been involved in teaching activities and supervising the scientific training of students (National School of Health-ISCIII, European University and IRYCIS).