HIV/Infectious Diseases Researching Group
Hospital General Universitario de Alicante, Instituto de Investigación Sanitario y Biomédica de Alicante, ISABIAL.
The HIV/Infectious Diseases Researching Group of the Hospital General Universitario and “Instituto de Investigación Sanitaria y Biomédica de Alicante, ISABIAL” is integrated in the Spanish AIDS Research Network (RIS) from 2004, participating actively in the field of HIV researching and collaborating with other Spanish groups integrated in the RIS and other groups of the European AIDS Treatment Network (NEAT).
Our group is composed by eight senior scientists: clinicians (5), virologists (2), epidemiologists (1), and young researchers constituted by pharmacists, psychologist, biotechnologist, nurses, and training doctors in Internal Medicine and Infectious Diseases, Microbiology and Epidemiology and Public Health, who coordinate and collaborate in clinical trials and observational studies.
Our collaborative lines of researching are the following:
- Antiretroviral treatment and hepatitis C treatment in the setting of Clinical Trials with new antiviral drugs or new combination regimens. We have participated in important clinical trials which have modified antiretroviral treatment guidelines: EMERALD (Lancet HIV, 2017), NEAT001/ANRS143 (Lancet 2014, J Antimicrob Chemother 2016, Lancet HIV 2015, HIV Med 2015); SINGLE Study (N Eng J Med 2013, J Acquir Immune Defic Syndr 2015); SALT study (Lancet Infect Dis 2015); OLE/RIS-EST13 study (Lancet Infect Dis 2015); ATADAR study (Clin Infect Dis 2015); KRETA study (J Antimicrob Chemother 2013); SPRING-2 study (Lancet 2013); SPIRAL study (AIDS 2012); STARTMRK study (J Acquir Immune Defic Syndr 2013; HIV Clin Trials 2012); ECHO and THRIVE trials (J Antimicrob Chemother 2012), etc.
- Epidemiological and observational studies about clinical HIV infection, antiretroviral treatment toxicity, HIV-HCV co-infection and non-AIDS clinical events in the setting of RIS and NEAT researching.
As a researching group, we are especially interested in the following exploring lines:
- Chronic inflammation and bacterial translocation in patients with HIV infection and its relationship with different non-AIDS events, particularly subclinical atherosclerosis and cardiovascular disease.
- HIV-associated neurocognitive disorder (HAND). In this field, we are interested on the associated factors to HAND, including chronic inflammation and bacterial translocation, and the outcome of patients diagnosed of asymptomatic neurocognitive disorder.
- Endocrinology disorders in HIV patients: insulin-resistance, diabetes mellitus, vitamin D deficiency, fertility and hypogonadism.
- HIV-HCV co-infection (treatment and hepatocellular carcinoma) and HPV-HIV co-infection (prevention of anal carcinoma).
- In the previous researching lines, we have conducted four Doctoral Thesis, scientific communications to National and International Conferences and published different scientific articles (Eur J Clin Invest. 2017, HIV Med 2016, AIDS 2014; J Int AIDS Soc, 2014; HIV Med 2013, J Acquir Immune Defic Syndr 2013; Antivir Ther, 2013; Med Clin, 2014, Clin Infect Dis, 2013, AIDS 2010).