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null HIV/AIDS Research Group-General University Hospital of Elche
Hospital General Universitario de Elche (Alicante)

Description

The HIV / AIDS research group of the General University Hospital of Elche has a long experience in clinical and epidemiological research on different aspects of HIV infection. It is part of the AIDS Research Network since its establishment and participates in different competitive studies at national and international level. The group has led several research projects on complications of HIV infection and antiretroviral treatment that have allowed the publication of more than 100 scientific articles in top journals in the last 10 years. We have a particular interest in the study of the key factors that determine the progression of atherosclerosis in patients receiving antiretroviral treatment and the possible therapeutic interventions to slow progression. We have a fully equipped Vascular Laboratory, and we have a long experience in the evaluation of subclinical arteriosclerosis by carotid ultrasound and in the measurement of endothelial function by endothelium-dependent vasodilation. The Unit and the Hospital Research Laboratory are well equipped for processing biological samples and carrying out biochemical techniques, flow cytometry and molecular biology.

Lines of research:

  1. Progression of arteriosclerosis in patients with HIV infection in antiretroviral therapy: pathogenic mechanisms and biological and morphological predictors of progression.
  2. Comorbidities and aging. Frequency and characteristics of non-AIDS events. Predictors and impact.
  3. Residual risk of transmission in men with HIV treated with antiretrovirals who have sex with other men.
  4. Predictors of long-term virological suppression and characterization of the associated immuno-inflammatory responses and changes in oxidative stress and in the biological leukocyte age.

Major contributions of the group are: 

  1. Recognition of C-reactive protein and oxidative stress as markers of cardiovascular disease and mortality in HIV-infected patients on cART.
  2. Disclosing that endothelial function is impaired in patients with lipodystrophy.
  3. Description that a number of coinfections may play a role in the progression of artheriosclerosis, including hepatitis C virus, cytomegalovirus and varicella zoster, and herpes virus 8.
  4. Describing risk and predictors of different non-AIDS diseases in HIV-infected patients including cardiovascular events and of the contribution of oxidative stress to development of non-AIDS diseases.
  5.  Conducting the first randomized clinical trial comparing an intensive versus a standard intervention in stable HIV-infected patients with moderate-high cardiovascular risk.

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Members

Félix Gutiérrez
Araceli Adsuar
Vanesa Agullo
Xavier Barber
Marta Fernández
Elena García
Javier García
José Alberto García
Mar Masia
Vladimir Ospino
Sergio Padilla
Rafael Pascual
Catalina Robledano
Sacramento López
Yolanda Peral
Fina Valero

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Publications

  • Coinfection with human herpesvirus 8 is associated with persistent inflammation and immune activation in virologically suppressed HIV-infected patients. 
    Masiá M, Robledano C, Ortiz de la Tabla V, Antequera P, Lumbreras B, Hernández I, Gutiérrez F.  PLoS One. 2014 Aug 18;9(8):e105442. doi:10.1371/journal.pone.0105442. eCollection 2014. PubMed PMID: 25133669; PubMed Central PMCID: PMC4136871. 
  • Contribution of Oxidative Stress to Non-AIDS Events in HIV-Infected Patients 
    Masiá M, Padilla S, Fernández M, Barber X, Moreno S, Iribarren JA, Portilla J, Peña A, Vidal F, Gutiérrez F; CoRIS.  J Acquir Immune Defic Syndr. 2017 Jun 1;75(2):e36-e44. doi: 10.1097/QAI.0000000000001287. PubMed PMID: 28107228. 
  • HIV-related Osteonecrosis Study Group. Osteonecrosis in patients infected with HIV: clinical epidemiology and natural history in a large case series from Spain. 
    Gutiérrez F, Padilla S, Masiá M, Flores J, Boix V, Merino E, Galindo J, Ortega E, López-Aldeguer J, Galera C;  J Acquir Immune Defic Syndr. 2006 Jul;42(3):286-92. Erratum in: J Acquir Immune Defic Syndr. 2006 Aug 15;42(5):650. PubMed PMID: 16763523. 
  • Long-term effects of an intensive intervention in HIV-infected patients with moderate-high atherosclerotic cardiovascular risk. 
    Masiá M, Bernal E, Robledano C, Padilla S, López N, Martínez E, Gutiérrez F.  J Antimicrob Chemother. 2014 Nov;69(11):3051-6. doi: 10.1093/jac/dku269. Epub 2014 Jul 18. PubMed PMID: 25038306. 
  • Performance of genotypic algorithms for predicting HIV-1 tropism measured against the enhanced-sensitivity Trofile coreceptor tropism assay. 
    Sánchez V, Masiá M, Robledano C, Padilla S, Ramos JM, Gutiérrez F.  J Clin Microbiol. 2010 Nov;48(11):4135-9. doi: 10.1128/JCM.01204-10. Epub 2010 Sep 22. PubMed PMID:20861336; PubMed Central PMCID: PMC3020874. 
  • Prediction of neuropsychiatric adverse events associated with long-term efavirenz therapy, using plasma drug level monitoring. 
    Gutiérrez F, Navarro A, Padilla S, Antón R, Masiá M, Borrás J, Martín-Hidalgo A.  Clin Infect Dis. 2005 Dec 1;41(11):1648-53. Epub 2005 Oct 19. PubMed PMID: 16267739. 
  • Relationship between ankle-brachial index and carotid intima-media thickness in HIV-infected patients. 
    Gutiérrez F, Bernal E, Padilla S, Hernández I, Masiá M.  AIDS. 2008 Jul 11;22(11):1369-71. doi: 10.1097/QAD.0b013e3282f7cb88. PubMed PMID:18580617. 
  • Risk, predictors, andmortality associated with non-AIDS events in newly diagnosed HIV-infected patients: role of antiretroviral therapy. 
    Masiá M, Padilla S, Álvarez D, López JC, Santos I, Soriano V, Hernández-QueroJ, Santos J, Tural C, del Amo J, Gutiérrez F; CoRIS.  AIDS. 2013 Jan 14;27(2):181-9. doi:10.1097/QAD.0b013e32835a1156. PubMed PMID: 23018442. 
  • Single-slice computed tomography and anthropometric skinfold analysis for evaluation of facial lipoatrophy in HIV-infected patients. 
    Padilla S, Gallego JA, Masiá M, Gutiérrez F.  Clin Infect Dis. 2004 Dec 15;39(12):1848-51. Epub 2004 Nov21. PubMed PMID: 15578410. 
  • The role of C-reactive protein as a marker for cardiovascular risk associated with antiretroviral therapy in HIV-infected patients. 
    Masiá M, Bernal E, Padilla S, Graells ML, Jarrín I, Almenar MV, Molina J, Hernández I, Gutiérrez F.  Atherosclerosis. 2007 Nov;195(1):167-71. Epub 2006 Oct 17. PubMed PMID:17049532. 

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